ANTIDEPRESSANT EFFECT OF ETHANOLIC EXTRACT OF MIMOSA PUDICA COMPARED WITH IMIPRAMINE IN MICE MODELS

Background: Depression was considered as mental illness worldwide. Various symptoms observed with depression are loss of interest, sad mood, disturbed sleep, low energy, and appetite. Mimosa pudica is a traditional medicine having various medicinal properties. Imipramine tricyclic antidepressant drug used in depression. This study to evaluate the activity ethanolic extract M. leaves imipramine mice models. Methods: Swiss albino weighing 20–25 g either sex involved study. In each study, animals were divided into five groups (n=6). Drug administered i.p. performed using tail suspension test (TST) forced swim (FST) Group 1 – control group, 2 received (10 mg/kg), Groups 3, 4, 5 (4, 6, 8 mg/kg). Results: The shows significant reduction immobility acute chronic TST FST (6 mg/kg) when compared other extracts (4 mg/kg Conclusions: concluded that has can be, further, for treatment